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3,4-Dihydroxyphenylethanol attenuates Spatio-cognitive deficits in an Alzheimers disease mouse model: modulation of the molecular signals in neuronal survival-apoptotic programs

Depletion of glutathione peroxidase 4 (GPX4), an enzyme that lowers lipid hydroperoxides and inhibits lipid peroxidation, is the main cause of ferroptosis in B cells (81)

This complex allows the activation of caspase-9, which subsequently activates the effector caspases (caspases-3) that initiate DNA degradation [47]

One compelling histopathological correlate of disability progression is the slowly-expanding lesion, characterized by a presumably inactive gliotic demyelinated center surrounded by a rim of activated microglia and macrophages containing degenerated myelin, injured axons and often iron deposition (Dal-Bianco et al., 2017

Roberts, K.C., Moser, S.E., Collins, A.C., et al